%0 Journal Article %T Benzimidazoisoquinoline derivatives inhibit glioblastoma cell proliferation through down-regulating Raf/MEK/ERK and PI3K/AKT pathways %A Dong-Lin Yang %A Liu-Jun He %A Shi-Qiang Li %A Ya-Jun Zhang %A Yan Tang %A Zhi-Gang Xu %A Zhong-Zhu Chen %J Archive of "Cancer Cell International". %D 2018 %R 10.1186/s12935-018-0588-x %X Antiproliferation effects of benzimidazoisoquinoline derivatives in human glioblastoma cells. Chemical structures of the synthetic benzimidazoisoquinoline derivatives were labeled by compounds 1A¨CI. IC50 values were also obtained after 48 h with treatment of compounds 1A¨CI at concentrations of 3.125¨C50 ¦Ìmol/L in U87 and LN229 cells and represented as percentage of control as mean£¿¡À£¿SD of experiments performed at least three time %K Benzimidazoleisoquinolinone %K GBM %K S phase arrest %K Apoptosis %K PI3K/Akt pathway %K Raf/MEK/ERK pathway %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022716/