%0 Journal Article
%T Targeting Akt by SC66 triggers GSK-3¦Â mediated apoptosis in colon cancer therapy
%A Feng Wang
%A Jiangang Wang
%A Jie Ding
%A Nannan Liu
%A Shuang Peng
%A Yeying Liu
%A Yingjie Zhang
%A Yuan Huang
%J Archive of "Cancer Cell International".
%D 2019
%R 10.1186/s12935-019-0837-7
%X SC66 inhibited colon cancer cell proliferation in vitro. a Cell viability of HCT-116 was detected using cell counting kit-8 after 0, 0.5, 1, 2 or 4 ¦Ìg/ml SC66 treatment at indicated time. Data represent the mean£¿¡À£¿SEM of four independent experiments. b Cell viability was analyzed in various colon cancer cells after 2 ¦Ìg/ml SC66 treatment for 24 h. Data represent the mean£¿¡À£¿SEM of four independent experiments. c Western blotting analysis of P-Akt and Akt expression in HCT-116 WT treated with 2 ¦Ìg/ml SC66 treatment for 24 h. d Colony formation was analyzed by crystal violet staining in HCT-116 WT, HCT-116 p53£¿/£¿ and DLD1 cells following 2 ¦Ìg/ml SC66 treatment for 24 h. Similar results were obtained from three independent experiment
%K AKT
%K GSK-3¦Â
%K Bcl-xL
%K SC66
%K Colon cancer
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509835/