%0 Journal Article
%T Metabolic changes associated with methionine stress sensitivity in MDA-MB-468 breast cancer cells
%A Chiara Stringari
%A Dmitry Grapov
%A Enrico Gratton
%A Johannes Fahrmann
%A Michael Zeller
%A Oliver Fiehn
%A Peter Kaiser
%A Pierre Baldi
%A Ping Wang
%A Rupsa Datta
%A Stacey L. Borrego
%A Yumay Chen
%J Archive of "Cancer & Metabolism".
%D 2016
%R 10.1186/s40170-016-0148-6
%X The majority of cancer cells have a unique metabolic requirement for methionine that is not observed in normal, non-tumorigenic cells. This phenotype is described as ˇ°methionine dependenceˇ± or ˇ°methionine stress sensitivityˇ± in which cancer cells are unable to proliferate when methionine has been replaced with its metabolic precursor, homocysteine, in cell culture growth media. We focus on the metabolic response to methionine stress in the triple negative breast cancer cell line MDA-MB-468 and its methionine insensitive derivative cell line MDA-MB-468res-R8
%K Cancer metabolism
%K S-adenosylmethionine
%K SAM
%K Methionine
%K Homocysteine
%K Methionine stress
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852440/