%0 Journal Article
%T Repeat hepatectomy is independently associated with favorable longİ\term outcome in patients with colorectal liver metastases
%A Ashley R. Dennison
%A Christopher P. Neal
%A Gael R. Nana
%A Giuseppe Garcea
%A John Isherwood
%A Michael Jones
%A Vaux Cairns
%A Wee Ngu
%J Archive of "Cancer Medicine".
%D 2017
%R 10.1002/cam4.872
%X Up to threeİ\quarters of patients undergoing liver resection for colorectal liver metastases (CRLM) develop intrahepatic recurrence. Repeat hepatic resection appears to provide the optimal chance of cure for these patients. The aim of this study was to analyze shortİ\ and longİ\term outcomes following index and repeat hepatectomy for CRLM. Clinicopathological data were obtained from a prospectively maintained database. Perioperative variables and outcomes were compared using the Chiİ\squared test. Variables associated with longİ\term survival following index and second hepatectomy were identified by Cox regression analyses. Over the study period, 488 patients underwent hepatic resection for CRLM, with 71 patients undergoing repeat hepatectomy. There was no significant difference in rates of morbidity (P = 0.135), major morbidity (P = 0.638), or mortality (P = 0.623) when index and second hepatectomy were compared. Performance of repeat hepatectomy was independently associated with increased overall and cancerİ\specific survival following index hepatectomy. Short diseaseİ\free interval between index and second hepatectomy, number of liver metastases >1, and resection of extrahepatic disease were independently associated with shortened survival following repeat resection. Repeat hepatectomy for recurrent CRLM offers shortİ\term outcomes equivalent to those of patients undergoing index hepatectomy, while being independently associated with improved longİ\term patient survival
%K Colorectal cancer
%K metastasectomy
%K prognosis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313635/