%0 Journal Article
%T First-in-Human Phase 1 Trial of Agarose Beads Containing Murine RENCA Cells in Advanced Solid Tumors
%A Allyson J. Ocean
%A Angelica Nazarian
%A Anna Arreglado
%A Barry H. Smith
%A Daniel M. Levine
%A David J. Wolf
%A Eugene Akahoho
%A Joanne Thomas
%A Lawrence S. Gazda
%A Madeline Wiles
%A Nathaniel Berman
%A Tapan Parikh
%A Thomas J. Fahey
%A Thomas S. Parker
%A Zoe P. Andrada
%J Archive of "Cancer Growth and Metastasis".
%D 2016
%R 10.4137/CGM.S39442
%X Agarose macrobeads containing mouse renal adenocarcinoma cells (RMBs) release factors, suppressing the growth of cancer cells and prolonging survival in spontaneous or induced tumor animals, mediated, in part, by increased levels of myocyte-enhancing factor (MEF2D) via EGFR-and AKT-signaling pathways. The primary objective of this study was to determine the safety of RMBs in advanced, treatment-resistant metastatic cancers, and then its efficacy (survival), which is the secondary objective
%K solid tumors
%K cell-based therapeutics
%K cancer system biology
%K gastrointestinal cancer
%K cancer clinical trial
%K colorectal cancer treatment
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972125/