%0 Journal Article
%T Targeting cellular metabolism using rapamycin and/or doxycycline enhances anti-tumour effects in human glioma cells
%A Andr¨¢s Jeney
%A Anna Sebesty¨¦n
%A Enik£¿ Vetl¨¦nyi
%A Fanni T¨®th
%A G¨¢bor Pet£¿v¨¢ri
%A Hajnalka Rajnai
%A Ildik¨® Krencz
%A Katalin M¨¦sz¨¢ros
%A Krisztina Tak¨¢cs-Vellai
%A No¨¦mi Nagy
%A Regina Raffay
%A Titanilla Dank¨®
%A Zolt¨¢n Hujber
%J Archive of "Cancer Cell International".
%D 2018
%R 10.1186/s12935-018-0710-0
%X mTOR activity and metabolic differences in U251, U87 and U373-U human glioma cells. a mTOR activity related proteins and other metabolic enzyme expressions characterise and show some individual differences in the studied human glioma cell lines¡ªrepresentative figures of Western blot results; b the enzyme expression profiles could correlate to mTOR inhibitor sensitivity of glioma cells (rapamycin¡ªRapa 50 ng/mL; NVP-BEZ235¡ªBEZ 1 ¦ÌM; PP242 1 ¦ÌM for 72-h treatments), which were monitored by Alamar Blue and SRB proliferation tests¡ªthe cell proliferation of untreated controls was considered 100%; rapamycin inhibited the proliferation in all studied cells, significantly; Significant differences compared to rapamycin were labelled by *p£¿<£¿0.0
%K Glioblastoma
%K mTOR inhibitor
%K Anti-metabolic drug combinations
%K Tumour metabolism
%K Rapamycin
%K Doxycycline
%K Temozolomide
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300020/