%0 Journal Article
%T TGF-¦Â Sustains Tumor Progression through Biochemical and Mechanical Signal Transduction
%A Anastas Popratiloff
%A Christel H. Uittenbogaart
%A Christine A. Brantner
%A Douglas F. Nixon
%A Robert L. Furler
%J Archive of "Cancers".
%D 2018
%R 10.3390/cancers10060199
%X Transforming growth factor ¦Â (TGF-¦Â) signaling transduces immunosuppressive biochemical and mechanical signals in the tumor microenvironment. In addition to canonical SMAD transcription factor signaling, TGF-¦Â can promote tumor growth and survival by inhibiting proinflammatory signaling and extracellular matrix (ECM) remodeling. In this article, we review how TGF-¦Â activated kinase 1 (TAK1) activation lies at the intersection of proinflammatory signaling by immune receptors and anti-inflammatory signaling by TGF-¦Â receptors. Additionally, we discuss the role of TGF-¦Â in the mechanobiology of cancer. Understanding how TGF-¦Â dampens proinflammatory responses and induces pro-survival mechanical signals throughout cancer development is critical for designing therapeutics that inhibit tumor progression while bolstering the immune response
%K TGF-¦Â
%K cancer
%K immunosuppression
%K TAK1
%K mechanobiology
%K extracellular matrix
%K tensegrity
%K DNA damage
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025279/