%0 Journal Article
%T The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells
%A Andre Wegner
%A Andreas David Zimmer
%A Carole Goebel
%A Claude Haan
%A Iris Behrmann
%A Karsten Hiller
%A Nadia Battello
%A Xiangyi Dong
%J Archive of "Cancer & Metabolism".
%D 2016
%R 10.1186/s40170-016-0141-0
%X Hypoxia and inflammation have been identified as hallmarks of cancer. A majority of hepatocellular carcinomas are preceded by hepatitis B- or C-related chronic infections suggesting that liver cancer development is promoted by an inflammatory microenvironment. The inflammatory cytokine oncostatin M (OSM) was shown to induce the expression of hypoxia-inducible factor-1 ¦Á (HIF-1 ¦Á) under normoxic conditions in hepatocytes and hepatoma cells. HIF-1 ¦Á is known to orchestrate the expression of numerous genes, many of which code for metabolic enzymes that play key roles in the adaptation of cellular metabolism to low oxygen tension
%K Oncostatin M
%K Inflammation
%K Stable isotope labeling experiments
%K Hypoxia-inducible factor
%K Pyruvate dehydrogenase complex
%K Pyruvate dehydrogenase kinase
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756539/