%0 Journal Article
%T Trend analysis and survival of primary gallbladder cancer in the United States: a 1973¨C2009 populationİ\based study
%A Chester Schmaltz
%A Christian S. Jackson
%A Eduardo J. Simoes
%A Jamal A. Ibdah
%A Rubayat Rahman
%J Archive of "Cancer Medicine".
%D 2017
%R 10.1002/cam4.1044
%X Primary gallbladder cancer is an aggressive and uncommon cancer with poor outcomes. Our study examines epidemiology, trend, and survival of gallbladder cancer in the United States from 1973 to 2009. We utilized the Surveillance Epidemiology and End Results database (SEER). Frequency and rate analyses on demographics, stage, and survival were compared among nonİ\Hispanic whites, Hispanics, African American, and Asian/Pacific Islanders. A total of 18,124 cases were reported in SEER from 1973 to 2009 comprising 1.4% of all reported gastrointestinal cancers. Gallbladder cancer was more common in females than males (71 vs. 29%, respectively). The ageİ\adjusted incidence rate was 1.4 per 100,000, significantly higher in females than males (1.7 vs. 1.0). Trend analysis showed that the incidence rate has been decreasing over the last three decades for males. However, among females, the incidence rate had decreased from 1973 to midİ\90s but has remained stable since then. Trend analysis for stage at diagnosis showed that the proportion of lateİ\stage cases has been increasing significantly since 2001 after a decreasing pattern since 1973. Survival has improved considerably over time, and survival is better in females than males and in Asian/Pacific Islanders than other racial groups. The highest survival was in patients who received both surgery and radiation. Trend analysis revealed a recent increase of the incidence of lateİ\stage gallbladder cancer. Highest survival was associated with receiving both surgery and radiation
%K Epidemiology
%K gallbladder cancer
%K incidence trend
%K SEER
%K survival trend
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387125/