%0 Journal Article
%T Anti-cancer Effects of a Novel Quinoline Derivative 83b1 on Human Esophageal Squamous Cell Carcinoma through Down-Regulation of COX-2 mRNA and PGE2
%A Albert Sun Chi Chan
%A Alfred King Yin Lam
%A Chung Hin Chui
%A Dessy Chan
%A Ivan Ho Yuen Pun
%A Johnny Cheuk On Tang
%A Kim Hung Lam
%A Po Yee Chung
%A Sau Hing Chan
%A Simon Law
%A Yuan Yuan Zhou
%J Archive of "Cancer Research and Treatment : Official Journal of Korean Cancer Association".
%D 2017
%R 10.4143/crt.2016.190
%X 83b1 is a novel quinoline derivative that has been shown to inhibit cancer growth in human esophageal squamous cell carcinoma (ESCC). This study was conducted to comprehensively evaluate the cytotoxic effects of 83b1 on a series of ESCC cell lines and investigate the mechanisms by which 83b1 suppresses cancer growth based on molecular docking analysis
%K Quinolines
%K Esophageal squamous cell carcinoma
%K PPAR delta
%K Cyclooxygenase 2
%K Dinoprostone
%K Cell cytotoxicity
%K Reverse transcription polymerase chain reaction
%K Real-time polymerase chain reaction
%K Nude-mice
%K Heterografts
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266386/