%0 Journal Article
%T Inflammation and Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma: Fighting Against Multiple Opponents
%A Farid G Khalafalla
%A Mohammad W Khan
%J Archive of "Cancer Growth and Metastasis".
%D 2017
%R 10.1177/1179064417709287
%X Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and one of the most lethal human cancers. Inflammation is a critical component in PDAC initiation and progression. Inflammation also contributes to the aggressiveness of PDAC indirectly via induction of epithelial-mesenchymal transition (EMT), altogether leading to enhanced resistance to chemotherapy and poor survival rates. This review gives an overview of the key pro-inflammatory signaling pathways involved in PDAC pathogenesis and discusses the role of inflammation in induction of EMT and development of chemoresistance in patients with PDAC
%K Inflammation
%K PDAC
%K EMT
%K chemoresistance
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436837/