%0 Journal Article
%T Effects of exenatide on cardiac function, perfusion, and energetics in type 2 diabetic patients with cardiomyopathy: a randomized controlled trial against insulin glargine
%A Adriaan A. Lammertsma
%A Albert C. van Rossum
%A Hendrik J. Harms
%A Karin de Boer
%A Lourens F. H. J. Robbers
%A Mark H. H. Kramer
%A Michaela Diamant
%A Paul Knaapen
%A Weena J. Y. Chen
%J Archive of "Cardiovascular Diabetology".
%D 2017
%R 10.1186/s12933-017-0549-z
%X Multiple bloodglucose-lowering agents have been linked to cardiovascular events. Preliminary studies showed improvement in left ventricular (LV) function during glucagon-like peptide-1 receptor agonist administration. Underlying mechanisms, however, are unclear. The purpose of this study was to investigate myocardial perfusion and oxidative metabolism in type 2 diabetic (T2DM) patients with LV systolic dysfunction as compared to healthy controls. Furthermore, effects of 26-weeks of exenatide versus insulin glargine administration on cardiac function, perfusion and oxidative metabolism in T2DM patients with LV dysfunction were explored
%K Diabetes mellitus type 2
%K Exenatide
%K Cardiac function
%K Myocardial perfusion
%K Myocardial oxidative metabolism
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438489/