%0 Journal Article
%T Inhibition of dynamin-related protein 1 protects against myocardial ischemia¨Creperfusion injury in diabetic mice
%A Cong Huo
%A Feng Fu
%A Mingge Ding
%A Qianqian Dong
%A Xiaoming Wang
%A Xin Jia
%A Xing Li
%A Yinxian Qu
%A Zheng Liu
%A Zhenghua Liu
%J Archive of "Cardiovascular Diabetology".
%D 2017
%R 10.1186/s12933-017-0501-2
%X Many cardioprotective pharmacological agents failed to exert their protective effects in diabetic hearts subjected to myocardial ischemia/reperfusion (MI/R). Identify the molecular basis linking diabetes with MI/R injury is scientifically important and may provide effective therapeutic approaches. Dynamin-related protein 1 (Drp1)-mediated mitochondrial fission plays an important role in MI/R injury under non-diabetic conditions. Importantly, recent studies indicated that Drp1-mediated mitochondrial fission is enhanced in the myocardium of diabetic mice. The above evidences suggested that Drp1 may be one critical molecule linking diabetes with MI/R injury. We hypothesized that inhibition of Drp1 may be effective to reduce MI/R injury in diabetic hearts
%K Drp1
%K Mitochondrial fission
%K Diabetes
%K Ischemia¨Creperfusion
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297196/