%0 Journal Article
%T Genome©\wide DNA methylation profiling shows molecular heterogeneity of anaplastic pleomorphic xanthoastrocytoma
%A Junji Ikeda
%A Junko Hirato
%A Kai Yamasaki
%A Kensuke Tateishi
%A Kohei Fukuoka
%A Koichi Ichimura
%A Naoko Udaka
%A Norio Shiba
%A Reo Tanoshima
%A Satoshi Yamashita
%A Shoji Yamanaka
%A Taishi Nakamura
%A Tetsuya Yamamoto
%A Yoshiko Nakano
%A Yuko Matsushita
%J Archive of "Cancer Science".
%D 2019
%R 10.1111/cas.13903
%X In the revised World Health Organization classification 2016, anaplastic pleomorphic xanthoastrocytoma (PXA) has been newly defined as a variant of the PXA entity. Furthermore, some anaplastic PXA were reported to have extremely poor prognosis which showed a type of pediatric glioblastoma (GBM) molecular profile. Recent integrated molecular classification for primary central nervous system tumors proposed some differences between histological and molecular features. Herein, in a genome©\wide molecular analysis, we show an extreme aggressive anaplastic PXA that resulted in a pediatric GBM molecular profile. A full implementation of the molecular approach is the key to predict prognosis and decide the treatment strategy for anaplastic PXA
%K anaplastic PXA
%K brain tumor
%K CpG island
%K DNA methylation
%K pediatric glioblastoma
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361572/