%0 Journal Article
%T Histopathological analysis of papillary thyroid carcinoma detected during ultrasound screening examinations in Fukushima
%A Manabu Iwadate
%A Masahiro Ito
%A Mykola D. Tronko
%A Shinichi Suzuki
%A Shunichi Yamashita
%A Tatiana I. Rogounovitch
%A Tetiana I. Bogdanova
%A Vladimir A. Saenko
%A Yuko Hashimoto
%J Archive of "Cancer Science".
%D 2019
%R 10.1111/cas.13912
%X Thyroid ultrasound screening of young residents in Fukushima Prefecture, Japan, showed a high detection rate of papillary thyroid carcinoma (PTC). Detailed morphological analysis of these tumors was not presented to date. This study sets out to evaluate changes in histopathological and invasive characteristics of Fukushima PTC with time after the nuclear accident of March 2011 in all available cases and in different age subgroups. Histological specimens of 115 PTCs from patients aged 18 years or younger at the time of the Fukushima Daiİ\ichi Nuclear Power Plant accident, who underwent surgical resection at Fukushima Medical University during 2012İ\2016, were reviewed. Patients were divided into those treated during the first 4 years after the accident (n = 78, shorterİ\onset) or later (n = 37, longerİ\onset). The whole group and 3 age subgroups: children (aged less than 15 years), adolescents (aged from 15 to less than 19 years), and young adults (aged from 19 years) at surgery were analyzed. No statistically significant timeİ\related changes in tumor structure or invasiveness were found in the whole group or in ageİ\matched subgroups. Statistically significant ageİ\related downtrend was observed for intrathyroid spread in the whole group of patients. The absence of temporal changes in tumor morphological characteristics and tumor invasiveness strongly suggests common etiology of the shorterİ\ and longerİ\onset Fukushima PTCs, which are unlikely related to the effect of exposure to very low doses of radiation
%K comparative study
%K Fukushima nuclear accident
%K mass screening
%K papillary thyroid carcinoma
%K surgical pathology
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361578/