%0 Journal Article %T Efficacy and safety of canagliflozin in combination with insulin: a double-blind, randomized, placebo-controlled study in Japanese patients with type 2 diabetes mellitus %A Hiroaki Iijima %A Maki Goda %A Nobuko Maruyama %A Nobuya Inagaki %A Shin-ichi Harashima %A Yutaka Kawaguchi %J Archive of "Cardiovascular Diabetology". %D 2016 %R 10.1186/s12933-016-0407-4 %X Combination therapy with canagliflozin and insulin was investigated in a prescribed substudy of the canagliflozin Cardiovascular Assessment Study (CANVAS); however, it was not evaluated in Japanese patients with type 2 diabetes mellitus (T2DM). Since the usage profile of insulin therapy and pathologic features of Japanese patients differ from those of Caucasian patients, we determined the clinical benefit of such a combination therapy in Japanese patients %K Canagliflozin %K Combination therapy %K Insulin %K Japanese patients %K SGLT2 inhibitor %K Type 2 diabetes mellitus %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912792/