%0 Journal Article
%T Effects of Vacuolar H+-ATPase Inhibition on Activation of Cathepsin B and Cathepsin L Secreted from MDA-MB231 Breast Cancer Cells
%A Andrew Uhlman
%A Ayana Hinton
%A Harshida Pancholi
%A Jared Liston
%A Kelly Folkers
%J Archive of "Cancer Microenvironment".
%D 2017
%R 10.1007/s12307-017-0196-7
%X Activity of cathepsins B and L in conditioned media and cell lysates following V-ATPase inhibition. Conditioned media (a) and cell lysates (b) from cells grown for 24 h in the absence (0 nM) or presence (100 nM) of concanamycin A were assayed for cathepsin activity. N = 5, error bars ¨C std. dev, Student t test * p < 0.005, ** p < 0.0001. (c) Percent reduction in cathepsin activity following treatment with concanamycin A in conditioned media (CM) and cell lysates (Lysate). N = 5, error bars ¨C std. dev., Student t test *** p < 0.0
%K Vacuolar H+-ATPase
%K Cysteine cathepsins
%K Breast cancer cells
%K Tumor microenvironment
%K Protease activation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750200/