%0 Journal Article
%T Downregulation of long non©\coding RNA Opa interacting protein 5©\antisense RNA 1 inhibits breast cancer progression by targeting sex©\determining region Y©\box 2 by microRNA©\129©\5p upregulation
%A Dilihumaer Tuluhong
%A Hanjun Li
%A Huijuan Zeng
%A Jieshou Li
%A Jing Chen
%A Jingjie Wang
%A Kai Zhang
%A Lulu Wang
%A Shaohua Wang
%A Tao Chen
%J Archive of "Cancer Science".
%D 2019
%R 10.1111/cas.13879
%X Several studies have shown an important role for long non©\coding RNA (lncRNA) in breast cancer progression. The present study investigated the role of lncRNA Opa interacting protein 5©\antisense RNA 1 (OIP5©\AS1) in the progression of breast cancer. OIP5©\AS1 was significantly upregulated in breast cancer tissues and in breast cancer cell lines, and OIP5©\AS1 downregulation inhibited the malignant behavior of breast cancer in vitro and in vivo. For in©\depth exploration of the mechanism of OIP5©\AS1 in breast cancer, we found that expression of microRNA©\129©\5p(miR©\129©\5p), which was found to bind sites in the sequence of OIP5©\AS1, in breast cancer tissues was negatively correlated with OIP5©\AS1. Also, luciferase assays indicated that OIP5©\AS1 acted as a miR©\129©\5p sponge, resulting in upregulated expression of the sex©\determining region Y©\box 2 (SOX2) transcription factor. Our study showed that OIP5©\AS1 plays a critical role in promoting breast cancer progression and that OIP5©\AS1 downregulation targets SOX2 by miR©\129©\5p upregulation
%K breast cancer
%K ceRNA
%K lncRNA
%K malignant phenotype
%K miR©\129©\5p
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317922/