%0 Journal Article
%T ¦Á11¦Â1 Integrin is Induced in a Subset of Cancer-Associated Fibroblasts in Desmoplastic Tumor Stroma and Mediates In Vitro Cell Migration
%A Anders Molven
%A C¨¦dric Zeltz
%A Daniela-Elena Costea
%A Donald Gullberg
%A Edna Cukierman
%A Heinz Hoschuetzky
%A Hengshuo Liu
%A Himalaya Parajuli
%A Jahedul Alam
%A Ning Lu
%A Pugazendhi M. Erusappan
%J Archive of "Cancers".
%D 2019
%R 10.3390/cancers11060765
%X Integrin ¦Á11¦Â1 is a collagen receptor that has been reported to be overexpressed in the stroma of non-small cell lung cancer (NSCLC) and of head and neck squamous cell carcinoma (HNSCC). In the current study, we further analyzed integrin ¦Á11 expression in 14 tumor types by screening a tumor tissue array while using mAb 203E3, a newly developed monoclonal antibody to human ¦Á11. Different degrees of expression of integrin ¦Á11 were observed in the stroma of breast, ovary, skin, lung, uterus, stomach, and pancreatic ductal adenocarcinoma (PDAC) tumors. Co-expression queries with the myofibroblastic cancer-associated fibroblast (myCAF) marker, alpha smooth muscle actin (¦ÁSMA), demonstrated a moderate level of ¦Á11+ in myCAFs associated with PDAC and HNSCC tumors, and a lack of ¦Á11 expression in additional stromal cells (i.e., cells positive for fibroblast-specific protein 1 (FSP1) and NG2). The new function-blocking ¦Á11 antibody, mAb 203E1, inhibited cell adhesion to collagen I, partially hindered fibroblast-mediated collagen remodeling and obstructed the three-dimensional (3D) migration rates of PDAC myCAFs. Our data demonstrate that integrin ¦Á11 is expressed in a subset of non-pericyte-derived CAFs in a range of cancers and suggest that ¦Á11¦Â1 constitutes an important receptor for collagen remodeling and CAF migration in the tumor microenvironment (TME)
%K tumor microenvironment
%K tumor stroma
%K extracellular matrix
%K fibrillar collagen
%K cancer-associated fibroblasts
%K integrin alpha11
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627481/