%0 Journal Article %T Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells %A Aashish Khanal %A Chen Guo %A En-Hao Kang %A Hai-Tao Niu %A Hong Li %A Qing-Hai Wang %A Tao Huang %A Wei Zhang %A Yan-Wei Cao %A Zhen Dong %J Archive of "Cancer Cell International". %D 2019 %R 10.1186/s12935-019-0889-8 %X The viability of 786-O cells and HUVECs in the co-culture mode and the control single-culture mode. a, b In the transwell culturing, 1£¿¡Á£¿104 cells were seeded in the upper chamber and 4£¿¡Á£¿104 cells were seeded in the lower chamber. The viability of (a) 786-O cells and (b) HUVECs was measured by a CCK-8 assay at 0, 24, 48, 72, and 96 h after culturing. For the control, the cells were seeded in both the upper and lower chambers; for the HUVEC coculture, 786-O cells were added to the upper chamber while HUVECs were added to the lower chamber; for the 786-O coculture, HUVECs were added to the upper chamber while 786-O cells were added to the lower chamber; and, for the control£¿+£¿7ACC1 or coculture£¿+£¿7ACC1, 10 ¦ÌM 7ACC1 was added to the culturing conditions. *P£¿<£¿0.001, compared with the contro %K Monocarboxylate transporter %K Glycolytic metabolism %K Renal cell carcinoma %K Cancer-endothelial microenvironment %K Cancer invasion %K Cancer metastasis %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599352/