%0 Journal Article
%T The Role of Forkhead Box Proteins in Acute Myeloid Leukemia
%A Carmelo Gurnari
%A Eleonora De Bellis
%A Emiliano Fabiani
%A Giulia Falconi
%A Maria Teresa Voso
%J Archive of "Cancers".
%D 2019
%R 10.3390/cancers11060865
%X Forkhead box (FOX) proteins are a group of transcriptional factors implicated in different cellular functions such as differentiation, proliferation and senescence. A growing number of studies have focused on the relationship between FOX proteins and cancers, particularly hematological neoplasms such as acute myeloid leukemia (AML). FOX proteins are widely involved in AML biology, including leukemogenesis, relapse and drug sensitivity. Here we explore the role of FOX transcription factors in the major AML entities, according to ˇ°The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemiaˇ±, and in the context of the most recurrent gene mutations identified in this heterogeneous disease. Moreover, we report the new evidences about the role of FOX proteins in drug sensitivity, mechanisms of chemoresistance, and possible targeting for personalized therapies
%K forkhead box proteins
%K acute myeloid leukemia
%K chemoresistance
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627614/