%0 Journal Article
%T Comparison of transcriptional profiles in human lymphocyte cells irradiated with 12C ion beams at 0¨C2.0 Gy
%A Ruifeng Zhang
%A Xuhong Dang
%A Yahui Zuo
%A Yayi Yuan
%A Yue Ren
%A Zhikai Duan
%A Zhongxin Zhang
%J Archive of "Cancer Management and Research".
%D 2019
%R 10.2147/CMAR.S188959
%X Heavy ions have contributed to tumor site-specific radiotherapy and are a major health risk for astronauts. The purpose of this study was to investigate the changes in gene expression in peripheral lymphocytes of cancer patients and astronauts exposed to 12C ions, and identify suitable molecular biomarkers for health monitoring. We also aimed to observe the effects of treatment and the level of damage, by comparing the transcriptional profiles of human lymphocyte cell lines exposed to 12C ion beams at doses of 0¨C2.0 Gy
%K 12C ion beams
%K human lymphocyte cell line
%K microarray assay
%K gene expression
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434914/