%0 Journal Article
%T The loss-of-function mutations and down-regulated expression of ASB3 gene promote the growth and metastasis of colorectal cancer cells
%A Chun-Mei Kuang
%A Jiang-Xue Wu
%A Ran-Yi Liu
%A Shuai Chen
%A Wen Ye
%A Wen-Lin Huang
%A Wu-Ying Du
%A Xiang Fu
%A Yi Zhou
%A Zhen-Hai Lu
%A Zhi-Zhong Pan
%J Archive of "Cancer Communications".
%D 2017
%R 10.1186/s40880-017-0180-0
%X Ankyrin repeat and SOCS box protein 3 (ASB3) is a member of ASB family and contains ankyrin repeat sequence and SOCS box domain. Previous studies indicated that it mediates the ubiquitination and degradation of tumor necrosis factor receptor 2 and is likely involved in inflammatory responses. However, its effects on oncogenesis are unclear. This study aimed to investigate the effects of ASB3 on the growth and metastasis of colorectal cancer (CRC)
%K Ankyrin repeat and SOCS box protein 3 (ASB3)
%K Colorectal cancer
%K Epithelial-mesenchymal transition
%K Cell proliferation
%K Tumor metastasis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237493/