%0 Journal Article
%T Effect of Daily Light on c-Fos Expression in the Suprachiasmatic Nucleus under Jet Lag Conditions
%A Hitoshi Okamura
%A Masao Doi
%A Toru Suzuki
%A Yulin Chen
%J Archive of "Acta Histochemica et Cytochemica".
%D 2018
%R 10.1267/ahc.18001
%X Jet-lag symptoms arise from temporal misalignment between the internal circadian clock and external solar time when traveling across multiple time zones. Light is known as a strong timing cue of the circadian clock. We here examined the effect of daily light on the process of jet lag by detecting c-Fos expression in the master clock neurons in the suprachiasmatic nucleus (SCN) under 8-hr phase-advanced jet lag condition. In WT mice, c-Fos-immunoreactivity was found at 1每2 hours on the first day after light/dark (LD) phase-advance. This induction was also observed on the second and third days, although their levels were diminished day by day. In contrast, c-Fos induction in the SCN of V1a每/每V1b每/每 mice, which show virtually no jet lag symptoms even after 8-hr phase-advance, was only detected on the first day. These results indicate that external light has affected SCN neuronal activity for 3 days after LD phase-advance in WT mice suggesting the continuous progress of activity change of SCN neurons under jet lag conditions. Noteworthy, limited c-Fos induction in V1a每/每V1b每/每 SCN is also consistent with the rapid reentrainment of the SCN clock in mutant mice after 8-hr LD phase-advance
%K circadian rhythm
%K suprachiasmatic nucleus
%K c-Fos
%K jet lag
%K vasopressin receptor
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976887/