%0 Journal Article
%T Novel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver Transplantation
%A Arjmand R. Mufti
%A Cathy Gentry
%A Christine S. Hwang
%A Kar¨Śn Matevosyan
%A Madhuri Vusirikala
%A Prapti A. Patel
%A Robert H. Collins
%A Shannan R. Tujios
%A Suntrea T. G. Hammer
%A Timothy J. Brown
%J Archive of "ACG Case Reports Journal".
%D 2017
%R 10.14309/crj.2017.48
%X A 48-year-old man with hepatitis C virus (HCV) cirrhosis complicated by hepatocellular carcinoma underwent liver transplantation. His course was complicated by fever, diarrhea, abdominal pain, and pancytopenia. He developed a diffuse erythematous rash, which progressed to erythroderma. Biopsies of the colon and skin were consistent with acute graft-versus-host disease. Donor-derived lymphocytes were present in the peripheral blood. The patient was treated with corticosteroids and cyclosporine; however, he had minimal response to intensive immunosuppressive therapy. Extracorporeal photopheresis was initiated as a salvage therapy. He had a dramatic response, and his rash, diarrhea, and pancytopenia resolved. He is maintained on minimal immunosuppression 24 months later
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371721/