%0 Journal Article
%T Discovery of a Selective Phosphoinositide-3-Kinase
(PI3K)-¦Ă Inhibitor (IPI-549) as an Immuno-Oncology Clinical
Candidate
%A Andr¨¦ Lescarbeau
%A Ann M. Rowley
%A Catherine A. Evans
%A Christian M. Martin
%A Culver Cheung
%A David G. Winkler
%A Erin E. Brophy
%A Erin L. O¡¯Hearn
%A Janid A. Ali
%A Jennifer
L. Proctor
%A Jennifer G. Hoyt
%A Johan A. Pradeilles
%A John R. Soglia
%A Jonathan
P. DiNitto
%A Louis Grenier
%A Martin R. Tremblay
%A Melissa M. Pink
%A Patrick O¡¯Hearn
%A Quentin Glenadel
%A Somarajan J. Nair
%A Stanley I. Goldstein
%A Tao Liu
%A Thomas Tibbitts
%A Vito J. Palombella
%J Archive of "ACS Medicinal Chemistry Letters".
%D 2016
%R 10.1021/acsmedchemlett.6b00238
%K IPI-549
%K PI3K-gamma inhibitor
%K phosphoinositide-3-kinase
%K isoform selectivity
%K neutrophil migration
%K immuno-oncology
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018865/