%0 Journal Article
%T Genetic susceptibilty and celiac disease: what role do HLA haplotypes play?
%A Bonaguri Chiara
%A Di Mario Francesco
%A Fornaroli Fabiola
%A Gaiani Federica
%A Leandro Gioacchino
%A Luigi de¡¯Angelis Gian
%A Sciurti Martina
%J Archive of "Acta Bio Medica : Atenei Parmensis".
%D 2018
%R 10.23750/abm.v89i9-S.7953
%X Celiac disease is a chronic immune-mediated enteropathy triggered by exposure to dietary gluten in genetically predisposed individuals. Many genes involved in the pathogenesis have been identified and a crucial role is known to be played by the Human Leukocyte Antigen (HLA) system. The main determinants for genetic susceptibility are HLA-DQA1 and HLA-DQB1 genes encoding for HLA-DQ2 and HLA-DQ8 molecules, carried by almost all patients affected. However, since HLA-DQ2 and HLA-DQ8 heterodimers explain almost 40% of the disease heritability, HLA typing should not be applied in diagnosis, but exclusively to clarify uncertain diagnoses, considering its negative predictive value. (www.actabiomedica.it
%K celiac disease
%K HLA typing
%K diagnostics
%K genetic predisposition
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502200/