%0 Journal Article
%T Hereditary Persistence of Alpha-Fetoprotein Is Associated with the £¿119G>A Polymorphism in AFP Gene
%A D. Nageshwar Reddy
%A Govardhan Bale
%A Mohan Ramchandani
%A Mohsin Aslam
%A Neha Deshpande
%A Radhika Chavan
%A Urmila Steffie Avanthi
%A V. V. Ravikanth
%J Archive of "ACG Case Reports Journal".
%D 2017
%R 10.14309/crj.2017.33
%X Alpha-fetoprotein (AFP) is a glycoprotein that is produced by the liver and yolk sac during fetal development. Its levels are usually raised in malignant conditions. Hereditary persistence of AFP (HPAFP) is a rare benign condition with elevated levels of AFP. It is inherited in a dominant mode with complete penetrance and is usually not associated with any clinical disability. We report two individuals with elevated levels of AFP harboring the £¿119G>A polymorphism in the AFP gene. A genetic screening to rule out variants in the AFP gene is advised in cases with unexplained persistent AFP levels to avoid inappropriate treatment and surgical options
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340718/