%0 Journal Article
%T Checkpoint Inhibitor¨CInduced Colitis: A New Type of Inflammatory Bowel Disease?
%A Emanuelle Bellaguara
%A Madeline Bertha
%A Stephen Hanauer
%A Timothy Kuzel
%J Archive of "ACG Case Reports Journal".
%D 2017
%R 10.14309/crj.2017.112
%X Checkpoint inhibitors are immune-stimulatory antibodies that have transformed the management and prognosis of individuals with metastatic melanoma and other cancers. Checkpoint inhibitor¨Cinduced colitis is an increasingly recognized immune-related adverse event that shares many of the same phenotypical, serological, and histological characteristics of both Crohn¡¯s disease and ulcerative colitis, suggesting that checkpoint inhibitor¨Cinduced colitis may represent a new inflammatory bowel disease phenotype. We report a 73-year-old man with metastatic melanoma who developed ipilimumab-induced colitis with subsequent transformation to Crohn?s colitis-like phenotype after the addition of pembrolizumab
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636906/