%0 Journal Article
%T Chronic Granulomatous Disease Mimicking Colonic Crohn¡¯s Disease Successfully Treated with Infliximab
%A Antš®nio Sarmento
%A Armando Peixoto
%A Fernando Magro
%A Guilherme Macedo
%A Rosa Coelho
%A Tiago Maia
%J Archive of "ACG Case Reports Journal".
%D 2017
%R 10.14309/crj.2017.46
%X Chronic granulomatous disease (CGD) is a genetically induced disease caused by mutations in one of the components of the NADPH-oxidase in phagocytes, characterized by life-threatening bacterial and fungal infections and granuloma formation. Treatment includes prevention of infectious complications and immunomodulation. However, a standard strategy is not yet defined. The authors report an X-linked CGD female carrier who presented during adulthood with diarrhea and colorectal ulcers, with high impairment of quality of life. Induction with infliximab 5 mg/kg (weeks 0, 2, and 6) with infectious prophylaxis was initiated. She continued infliximab 5 mg/kg every 8 weeks with complete symptomatic response at 15 months
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371719/