%0 Journal Article
%T Ebi, a Drosophila homologue of TBL1, regulates the balance between cellular defense responses and neuronal survival
%A Leo Tsuda
%A Young-Mi Lim
%J Archive of "American Journal of Neurodegenerative Disease".
%D 2016
%X Transducin ¦Â-like 1 (TBL1), a transcriptional co-repressor complex, is a causative factor for late-onset hearing impairments. Transcriptional co-repressor complexes play pivotal roles in gene expression by making a complex with divergent transcription factors. However, it remained to be clarified how co-repressor complex regulates cellular survival. We herein demonstrated that ebi, a Drosophila homologue of TBL1, suppressed photoreceptor cell degeneration in the presence of excessive innate immune signaling. We also showed that the balance between NF-¦ÊB and AP-1 is a key component of cellular survival under stress conditions. Given that Ebi plays an important role in innate immune responses by regulating NF-¦ÊB activity and inhibition of apoptosis induced by associating with AP-1, it may be involved in the regulation of photoreceptor cell survival by modulating cross-talk between NF-¦ÊB and AP-1
%K Redox-dependent transcription factors
%K ebi
%K TBL1
%K AP-1
%K NF-kappaB
%K Drosophila
%K innate immune signaling
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788732/