%0 Journal Article %T Monte Carlo simulations of randomized clinical trials in epilepsy %A Evan Myers %A Joseph Tharayil %A Robert Moss %A William H. Theodore %J Archive of "Annals of Clinical and Translational Neurology". %D 2017 %R 10.1002/acn3.426 %X The placebo response in epilepsy randomized clinical trials (RCTs) has recently been shown to largely reflect underlying natural variability in seizure frequency. Based on this observation, we sought to explore the parameter space of RCT design to optimize trial efficiency and cost %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553226/