%0 Journal Article
%T CD4+ T cells from multiple sclerosis patients respond to a commensal©\derived antigen
%A Anudeep B. Pant
%A Joseph N. Burgess
%A Lloyd H. Kasper
%J Archive of "Annals of Clinical and Translational Neurology".
%D 2017
%R 10.1002/acn3.465
%X Multiple sclerosis, an immune©\mediated disease of the central nervous system, is characterized by the impaired function of regulatory cells that fail to suppress self©\reactive effector cells. We have previously found that polysaccharide A, a capsular antigen derived from the human gut commensal Bacteroides fragilis, can induce a population of regulatory T cells. Herein, we demonstrate that na£¿ve T cells isolated from patients with multiple sclerosis have the capacity to acquire regulatory characteristics when stimulated in vitro with polysaccharide A. This study demonstrates the amplification of a regulatory T cell response by a gut©\derived commensal antigen in those with multiple sclerosis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682114/