%0 Journal Article
%T Glioblastoma in natalizumab©\treated multiple sclerosis patients
%A Dusan Stefoski
%A Fabian Sierra Morales
%A Jorge E. Novo
%A Leonidas D. Arvanitis
%A Robert B. Wright
%J Archive of "Annals of Clinical and Translational Neurology".
%D 2017
%R 10.1002/acn3.428
%X We present two natalizumab©\treated multiple sclerosis patients who developed glioblastoma multiforme (GBM) with variable outcomes. One patient had an isocitrate dehydrogenase (IDH)©\wildtype GBM with aggressive behavior, who declined treatment and died 13 weeks after symptoms onset. The other patient underwent resection of an IDH©\mutant secondary GBM that arose from a previously diagnosed grade II astrocytoma. He is still alive 5 years after the diagnosis of GBM. JC virus was not detected in either case. Whether natalizumab played a role in the development of GBM in those patients deserves further investigation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497532/