%0 Journal Article
%T Chronic tophaceous gout in patients with psoriasis
%A Antonio Pedro Mendes Schettini
%A J¨¦ssica Castiel Coutinho
%A La¨ªs Cruz Lobato
%A Maria Zeli Moreira Frota
%A M£¿nica Santos
%J Archive of "Anais Brasileiros de Dermatologia".
%D 2017
%R 10.1590/abd1806-4841.20174895
%X Psoriasis is a chronic inflammatory disease of multifactorial etiology influenced by genetic, immunological, and environmental factors. We report the case of a patient with psoriasis for more than 25 years who developed hyperuricemia and chronic tophaceous gout with unusual appearance. In psoriasis, hyperuricemia may occur by increased epidermal cell turnover, which accelerates purine metabolism and has uric acid as the product of its catabolism. The association of psoriasis with hyperuricemia can trigger the onset of gouty arthritis, and pose a greater risk of developing other inflammatory comorbidities. Therefore, it is important to periodically investigate uric acid levels in order to treat changes triggered by hyperuricemia
%K Gout
%K Psoriasis
%K Uric acid
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312188/