%0 Journal Article
%T The Association Between Constipation or Stool Consistency and Pain Severity in Patients With Chronic Pain
%A Hiroki Sakurai
%A Hironori Saisu
%A Kazuhiro Shimo
%A Keiko Owari
%A Kunio Kasugaii
%A Makoto Nishihara
%A Masayuki Inoue
%A Takahiro Ushida
%A Takako Matsubara
%A Tatsunori Ikemoto
%A Yasushi Funak
%A Young-Chang Arai
%A Yusuke Omichi
%J Archive of "Anesthesiology and Pain Medicine".
%D 2018
%R 10.5812/aapm.69275
%X Bacteria can influence a variety of gut functions. Some studies showed that stool consistency and constipation were associated with gut microbiome (GM) composition, and enterotype, dysbiosis. Growing evidence indicates the significant role of GM in the homeostatic function of the host body. The GM may regulate multiple neurochemical and neurometabolic pathways. Chronicity of the pain is actively modulated at the molecular to the network level by means of several neurotransmitters. The GM to some extent can affect pain perception
%K Gut Microbiome
%K Pain Severity
%K Stool Form
%K Constipation
%K Chronic Pain
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139698/