%0 Journal Article
%T Synthesis and In vitro Leishmanicidal Activities of Six Quercetin Derivatives
%A Ehsan Ostadhusseini
%A Lotfollah Saghaei
%A Maryam Mohajeri
%A Mustafa Ghanadian
%A Nader Pestechian
%A Sedighe Saberi
%J Archive of "Advanced Biomedical Research".
%D 2018
%R 10.4103/abr.abr_76_17
%X Today, leishmaniasis is a widespread, infectious parasitic disease caused by Leishmania spp. Natural-derived compounds are likely to provide a valuable source of new pharmaceuticals, and among them, quercetin derivatives may have antileishmanial effects. The antileishmanial activity of 3,5,7,3กฏ,4กฏ-pentahydroxyflavonol (quercetin) derivatives is partly attributed to the position and pKa of phenolic or catechol hydroxyl groups. Therefore, to optimize their leishmanicidal effect, the structural features of quercetin and its derivatives were improved by acylation or alkylation of hydroxyl groups and changing their pKa and consequently their activities
%K Leishmanicidal activity
%K quercetin derivatives
%K regioselective synthesis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952540/