%0 Journal Article
%T Genetic Interaction of APOE and FGF1 is Associated with Memory Impairment and Hippocampal Atrophy in AlzheimerĄŻs Disease
%A Chi-Wei Huang
%A Chiung-Chih Chang
%A Hiroaki Kazui
%A Shih-Wei Hsu
%A Shu-Hua Huang
%A Wen-Neng Chang
%A Ya-Ting Chang
%J Archive of "Aging and Disease".
%D 2019
%R 10.14336/AD.2018.0606
%X The APOE and fibroblast growth factor 1 (FGF1) have both been associated with amyloid ŠÂ accumulation and neurodegeneration. Investigation the effect of APOE-FGF1 interactions on episodic memory (EM) deficits and hippocampus atrophy (HA) might elucidate the complex clinical-pathological relationship in AlzheimerĄŻs disease (AD). EM performance and hippocampal volume (HV) were characterized in patients with mild AD based on APOE-ŠĆ4 carrier status (APOE-ŠĆ4 carriers versus non-carriers) and FGF1 single nucleotide polymorphism (FGF1-rs34011-GG versus FGF1-rs34011-A-allele carriers). The clinical-pathological relationships within each genotypic group (ŠĆ4+/GG-carrier, ŠĆ4+/A-allele-carrier, ŠĆ4-/GG-carrier and ŠĆ4-/A-allele-carrier) were analyzed. There were no significant differences between the FGF1-rs34011-GG and FGF1-rs34011-A-allele carriers for the level of EM performance or HV (p> 0.05). The bilateral HV was significantly smaller and EM impairment was significantly worse in ŠĆ4+/GG-carrier than in ŠĆ4-/A-allele-carrier, and an interaction effect of APOE (APOE-ŠĆ4 carriers versus non-carriers) with FGF1 (FGF1-rs34011-GG versus FGF1-rs34011-A-allele carriers) predicted EM impairment (F4,92= 3.516, p= 0.018) and structural changes in voxel-based morphometry. Our data shows that concurrent consideration of APOE and FGF1 polymorphisms might be required to understand the clinical-pathological relationship in AD
%K APOE
%K episodic memory
%K FGF1
%K genetic interaction
%K hippocampus
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538224/