%0 Journal Article
%T A composite measure of cognitive and functional progression in Alzheimer's disease: Design of the Capturing Changes in Cognition study
%A Andr¨¦ Aleman
%A Craig W. Ritchie
%A Frank Jan de Jong
%A John Harrison
%A Philip Scheltens
%A Sietske A.M. Sikkes
%J Archive of "Alzheimer's & Dementia : Translational Research & Clinical Interventions".
%D 2017
%R 10.1016/j.trci.2017.01.004
%X Cognitive testing in Alzheimer's disease (AD) is essential for establishing diagnosis, monitoring progression, and evaluating treatments. Assessments should ideally be brief, reliable, valid, and reflect clinically meaningful changes. There is a lack of instruments that meet all these criteria. In the Capturing Changes in Cognition (Catch-Cog) study, we seek to correct these deficiencies through the development and validation of a composite measure combining cognition and function: the cognitive-functional composite (CFC). We expect that the CFC is able to detect clinically relevant changes over time in early dementia stages of AD
%K Alzheimer's disease
%K Cognition
%K Composite measure
%K Daily function
%K Longitudinal construct validation
%K Mild cognitive impairment
%K Prospective cohort
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651369/