%0 Journal Article
%T Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment
%A Albert C. van Rossum
%A Albert de Roos
%A Anne-Sophie G.T. Bronzwaer
%A Astrid M. Hooghiemstra
%A Charlotte E. Teunissen
%A Doeschka A. Ferro
%A Esther E. Bron
%A Frank J.G. Backx
%A Frederik Barkhof
%A Geert J. Biessels
%A Heart Brain Connection study group
%A Janne M. Veerbeek
%A Johannes J. van Lieshout
%A Joost P.A. Kuijer
%A Leonie Franken
%A Marc B. Rietberg
%A Matthias J.P. van Osch
%A Niels D. Prins
%A Rahil Shahzad
%A Raquel Amier
%A Robin Nijveldt
%A Rosalie J. Huijsmans
%A Wiesje M. van der Flier
%A Wiro J. Niessen
%J Archive of "Alzheimer's & Dementia : Translational Research & Clinical Interventions".
%D 2017
%R 10.1016/j.trci.2017.02.002
%X There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini-Mental State Examination ¡Ý22 and Clinical Dementia Rating ¡Ü0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status
%K Cerebral blood flow
%K Exercise
%K Arterial spin labeling
%K Randomized clinical trial
%K Cognition
%K Vascular cognitive impairment
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651416/