%0 Journal Article
%T Plasma alpha©\synuclein detected by single molecule array is increased in PD
%A Adeline S. L. Ng
%A Ebonne Y. L. Ng
%A Eng©\King Tan
%A Fiona Setiawan
%A Kay Yaw Tay
%A Kumar M. Prakash
%A Nicole S. Y. Chia
%A Samuel Y. E. Ng
%A Wing Lok Au
%A Yi Jayne Tan
%A Zheyu Xu
%A Zhonghao Lu
%J Archive of "Annals of Clinical and Translational Neurology".
%D 2019
%R 10.1002/acn3.729
%X We utilized ultrasensitive single molecule technology to measure plasma alpha©\synuclein in 221 subjects (51 controls, 170 PD). Plasma alpha©\synuclein levels were significantly higher in PD than controls (15506.3 vs. 13057.0 pg/mL, P = 0.037), adjusting for age and gender. In PD, alpha©\synuclein levels did not vary by H&Y stage or UPDRS motor scores but were significantly higher in PD patients with poorer cognition (MMSE ¡Ü 25) than controls (P = 0.016, Bonferroni corrected P = 0.047). Alpha©\synuclein levels quantified using ultrasensitive single molecule technology discriminate PD from controls and correlate with cognitive severity. These preliminary findings require independent validation to determine the utility of this assay
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414476/