%0 Journal Article
%T Anti©\PrPC antibody rescues cognition and synapses in transgenic alzheimer mice
%A A. Harrison Brody
%A Andrew Billinton
%A Austin Stoner
%A Bhupinder Dosanjh
%A Claire Dobson
%A Erik C. Gunther
%A Gareth Rees
%A Iain Chessell
%A Jayne Hammersley
%A Laura T. Haas
%A Levi M. Smith
%A Maria Groves
%A Marius T. Chiasseu
%A Matthew Gardener
%A Timothy O. Cox
%A Tristan Vaughan
%J Archive of "Annals of Clinical and Translational Neurology".
%D 2019
%R 10.1002/acn3.730
%X Amyloid©\beta oligomers (AŁżo) trigger the development of Alzheimer's disease (AD) pathophysiology. Cellular prion protein (PrPC) initiates synaptic damage as a high affinity receptor for AŁżo. Here, we evaluated the preclinical therapeutic efficacy of a fully human monoclonal antibody against PrPC. This AZ59 antibody selectively targets the A¦Âo binding site in the amino©\terminal unstructured domain of PrPC to avoid any potential risk of direct toxicity
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414488/