%0 Journal Article
%T Dimethyl fumarate alters B©\cell memory and cytokine production in MS patients
%A Kyle A. Martin
%A Matthew D. Smith
%A Peter A. Calabresi
%J Archive of "Annals of Clinical and Translational Neurology".
%D 2017
%R 10.1002/acn3.411
%X We evaluated the effect of dimethyl fumarate (DMF) treatment on B©\cell memory and cytokine production in 18 patients with relapsing remitting multiple sclerosis (RRMS) using peripheral blood mononuclear cells obtained prior to and at 6 months post©\DMF initiation. We noted a decline in the absolute B©\cell number with DMF treatment, with a preferential depletion of memory B cells and a concurrent increase in na£¿ve B cells. We noted significant reductions in GM©\CSF, TNF©\¦Á, and IL©\6 producing B cells with DMF treatment. These effects on the B©\cell compartment may underlie the beneficial effects of DMF in RRMS
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420807/