%0 Journal Article
%T 1-Methyl-4-Phenylpyridinium-Induced Death of Differentiated SH-SY5Y Neurons Is Potentiated by Cholesterol
%A Anu Raju
%A Anupom Borah
%A Kochupurackal Parameswarannayar Mohanakumar
%A Parasuram Jaisankar
%J Archive of "Annals of Neurosciences".
%D 2018
%R 10.1159/000481551
%X Hypercholesterolemia is recently considered a risk factor for Parkinson's disease (PD), the most consistent neurodegenerative movement disorder. The study aimed to investigate the effect of exogenous cholesterol on 1-methyl-4-phenylpyridinium (MPP+) parkinsonian neurotoxin-induced cell death, loss of mitochondrial membrane potential, and dopaminergic deficiency in a cellular model of PD
%K Dopaminergic neurons
%K Cholesterol-induced neuronal death
%K Tyrosine hydroxylase
%K Cell viability
%K Mitochondrial membrane potential
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969353/