%0 Journal Article
%T Is transposition a defect of laterality?
%A John Stickley
%A Robert H Anderson
%J Archive of "Annals of Pediatric Cardiology".
%D 2018
%R 10.4103/apc.APC_122_18
%X In the investigation published in the current issue of the Journal, the team from Saudi Arabia have explored the troubled area of the potential association between transposition and defects of laterality. They have succeeded in bringing a degree of sanity to this topic. In order to appreciate the full significance of their analysis, we should remember that both of these issues were the source of significant previous controversies amongst those who investigate and treat patients with congenitally malformed hearts. For many years, the essential feature of transposition was considered to be the presence of the aortic root in anterior position,[1] rather than it its ˇ°normalˇ± location, which of course is posterior and rightward relative to the pulmonary root in those with usual arrangement of their organs. It was the landmark study of Van Praagh and his colleagues that showed that the arterial trunks could rarely arise from morphologically inappropriate ventricles even when the aortic root was positioned posteriorly and rightward, and with its leaflets in fibrous continuity with those of the mitral valve in the roof of an accompanying ventricular septal defect.[2] Since this recognition, it has become accepted that discordant ventriculo-arterial connections are the phenotypic feature of transposition.[3
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146863/