%0 Journal Article
%T Sparfloxacin-induced Nail Pigmentation: A Case of Fixed Drug Eruption?
%A Husain Yahya
%J Archive of "Annals of African Medicine".
%D 2018
%R 10.4103/aam.aam_16_17
%X Sparfloxacin, a synthetic, second generation, broad spectrum aminodifluoroquinolone antibiotic, has excellent penetration into respiratory tissues and has good activity against Gram-positive, Gram-negative, and atypical bacteria. Although it is indicated for the treatment of adult community-acquired pneumonia and acute exacerbation of chronic bronchitis, its use has been limited by phototoxicity which is more common with it than with other quinolones. We report a case of a 20-year-old Nigerian woman who developed a diffuse blue-black nail pigmentation of thumb and big toe nails, 2 weeks after completing therapy with sparfloxacin, and a recurrence of the pigmentation in the same nails 1 year after taking the drug again. We think this is likely a case of subungual fixed drug eruption. We briefly discuss the causes and mechanisms of drug-induced nail pigmentation in general
%K Drug-induced nail pigmentation
%K fixed drug eruption
%K sparfloxacin
%K Pigmentation des ongles induite par un m¨¦dicament
%K ¨¦ruption fixe des m¨¦dicaments
%K sparfloxacine
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810092/