%0 Journal Article
%T Hematological Indices in Malian Children Change Significantly during a Malaria Season and with Increasing Age: Implications for Malaria Epidemiological Studies
%A Ababacar Diouf
%A Abdoul S. Keita
%A Drissa Konate
%A Jennifer M. Anderson
%A Karim Traore
%A Kazutoyo Miura
%A Mahamadou Diakite
%A Mory Doumbouya
%A Rick M. Fairhurst
%A Saibou Doumbia
%A Seidina Diakite
%J Archive of "The American Journal of Tropical Medicine and Hygiene".
%D 2016
%R 10.4269/ajtmh.16-0125
%X Standard hematological indices are commonly used in malaria epidemiological studies to measure anemia prevalence and calculate blood parasite densities. In Africa, few studies have investigated how these indices change during a malaria transmission season and with increasing age. To address these knowledge gaps, we collected blood from 169 healthy Malian children aged 3每12 years before (May 2010) and after (January 2011) a transmission season. Red blood cell (RBC) count, hemoglobin (Hb) level, hematocrit (Ht), white blood cell (WBC) count, and WBC subsets were measured in paired blood samples, and the data were stratified by month (May, January) and age group (3每5, 6每8, and 9每12 years). From May to January, RBC count (4.53每4.70℅106/米L; P < 0.0001), Hb level (11.5每11.9 g/dL; P < 0.0001), and Ht (37.1每39.2%; P < 0.0001) increased, and WBC count (6.46每5.96℅103/米L; P = 0.0006) decreased. From May to January, the prevalence of WBC subsets also changed: 35每43% neutrophils, 6.5每7.6% monocytes, and 53每45% lymphocytes (P < 0.001). These seasonal changes were not associated with the number of malaria episodes experienced in the interim or the presence of RBC polymorphisms. In May, Hb (11.2, 11.4, and 11.8 g/dL; P = 0.0013) and Ht (36.5%, 36.7%, and 38.1%; P = 0.0154) increased and WBC count (8.04, 6.43, and 5.76℅103/米L; P < 0.0001) decreased with age group; similar differences were observed in January. These data suggest that season- and age-based reference values for hematological indices are needed to better estimate anemia prevalence and parasite density in malaria epidemiological studies
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973183/