%0 Journal Article
%T Colchicine-Induced Hepatotoxicity
%A Collette E. Abbott
%A Ruliang Xu
%A Samuel H. Sigal
%J Archive of "ACG Case Reports Journal".
%D 2017
%R 10.14309/crj.2017.120
%X Drug-induced injury (DILI) is a frequent cause of abnormal liver tests and a leading cause of liver failure in the United States. Colchicine has long been used as a systemic anti-inflammatory agent for treatment of gout by inhibiting mitotic activity and neutrophil function. We present the first case of colchicine-induced hepatoxicity, supported by histopathologic findings characteristic of colchicine-induced injury and resolution of liver enzyme abnormalities after its discontinuation. Colchicine-associated DILI has implications for the evaluation of patients with abnormal liver tests and gout, especially for patients with alcoholism and non-alcoholic fatty liver disease, in whom there is an increased incidence of gout
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703762/