%0 Journal Article
%T Budesonide-Related Iatrogenic Cushing¡¯s Syndrome in Microscopic Colitis
%A Kartikeya Tripathi
%A Thomas Dunzendorfer
%J Archive of "ACG Case Reports Journal".
%D 2017
%R 10.14309/crj.2017.5
%X Budesonide is the treatment of choice for microscopic colitis because of its excellent risk to benefit ratio. It is a potent, well-absorbed corticosteroid, but because of a high rate of first-pass metabolism in the liver, its systemic bioavailability is low. It has fewer corticosteroid-related adverse effects than prednisone, and adrenal suppression is considered to be rare. We present a middle-aged woman with lymphocytic colitis whose symptoms responded to budesonide but developed budesonide-related iatrogenic Cushing¡¯s syndrome. Withdrawal of budesonide led to restoration of normal pituitary-adrenal responsiveness but at the price of recurrent diarrhea due to re-emergence of lymphocytic colitis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244872/