%0 Journal Article %T A Pragmatic Guide to Establishing Clinical Decision Support Governance and Addressing Decision Support Fatigue: a Case Study %A Angela M. Wigren %A Brett L. Clayson %A Bruce E. Bray %A Carole H. Stipelman %A Carrie S. King %A Charlene R Weir %A Chris Walls %A Damian Borbolla %A David ElHalta %A Dean Taylor %A Guilherme Del Fiol %A Kensaku Kawamanto %A Mary H. Parsons %A Melissa S. Briley %A Michael C. Flynn %A Micheal B. Strong %A Polina Kukhareva %A Rachel Hess %A Teresa Taft %A Thomas J Reese %A Travis Gregory %J Archive of "AMIA Annual Symposium Proceedings". %D 2018 %X There is limited guidance available in the literature for establishing clinical decision support (CDS) governance and improving CDS effectiveness in a pragmatic, resource-efficient manner. Here, we describe how University of Utah Health established enterprise CDS governance in 2015 leveraging existing resources. Key components of the governance include a multi-stakeholder CDS Committee that vets new requests and reviews existing content; a requirement that proposed CDS is actually desired by intended recipients; coordination with other governance bodies; basic data analytics to identify high-frequency, low-value CDS and monitor progress; active solicitation of user issues; the transition of alert and reminder content to other, more appropriate areas in the electronic health record; and the judicious use of experimental designs to guide decision-making regarding CDS effectiveness. In the three years since establishing this governance, new CDS has been continuously added while the overall burden of clinician-facing alerts and reminders has been reduced by 53.8% %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371304/